Sarah Mellon (1903–1965) was the niece of Andrew W. Mellon (Secretary of the Treasury during the Great Depression). She was one of the heirs to the Mellon fortune, including Mellon Bank and major investments in Gulf Oil and Alcoa. In 1957, when Fortune prepared its first list of the wealthiest Americans, it estimated that Sarah Mellon, her brother Richard King Mellon, and her cousins Ailsa Mellon-Bruce and Paul Mellon were all amongst the richest eight people in the United States, with fortunes of between 400 and 700 million dollars each.
Sarah Mellon's son, Richard Mellon Scaife, is the owner–publisher of the Pittsburgh Tribune-Review.